Viazul (http://www.viazul.com/) provides several buses a day to/from Camagüey, Havana, Sancti Spiritus, and Santiago de Cuba. There is also daily service to Varadero, Cienfuegos, and Trinidad.
There are several trains to/from Havana each day. Camagüey and Santiago de Cuba are served by a daily overnight train and a twice weekly daytime local train that runs west on Thursdays and Sundays and east on Mondays and Fridays. A local train may leave Cienfuegos for Santa Clara very early in the morning, returning in the evening. Another local train may travel from Sancti Spiritus to Cienfuegos via Santa Clara in the morning, returning in the afternoon. Check that the local trains are running in advance.
Santa Clara has an international airport named Abel Santa Maria. This airport is used mostly by tourists who are going to all inclusives resorts in Cayo Santa Maria. Air Canada, Air Transat, Canjet, Wesjet and Cubana serve many Canadian cities from this airport
